Spatial coordination between cell and nuclear shape within micropatterned endothelial cells
نویسندگان
چکیده
منابع مشابه
Micropatterned surfaces for control of cell shape, position, and function.
The control of cell position and function is a fundamental focus in the development of applications ranging from cellular biosensors to tissue engineering. Using microcontact printing of self-assembled monolayers (SAMs) of alkanethiolates on gold, we manufactured substrates that contained micrometer-scale islands of extracellular matrix (ECM) separated by nonadhesive regions such that the patte...
متن کاملRadiation-induced expression of platelet endothelial cell adhesion molecule-1 in cerebral endothelial cells
Background: Radiation-induced molecular changes on the endothelial surface of brain arteriovenous malformations (AVM) may be used as markers for specific vascular targeting agents. In this study, we examined the level of expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) on brain endothelial cell surface after radiation treatment, with the aim of targeting the radiation-induc...
متن کاملMicropatterned structural control suppresses mechanotaxis of endothelial cells.
Vascular endothelial cell migration is critical in many physiological processes including wound healing and stent endothelialization. To determine how preexisting cell morphology influences cell migration under fluid shear stress, endothelial cells were preset in an elongated morphology on micropatterned substrates, and unidirectional shear stress was applied either parallel or perpendicular to...
متن کاملMicropatterning of single endothelial cell shape reveals a tight coupling between nuclear volume in G1 and proliferation.
Shape-dependent local differentials in cell proliferation are considered to be a major driving mechanism of structuring processes in vivo, such as embryogenesis, wound healing, and angiogenesis. However, the specific biophysical signaling by which changes in cell shape contribute to cell cycle regulation remains poorly understood. Here, we describe our study of the roles of nuclear volume and c...
متن کاملNuclear Shape in Muscle Cells
Every student of muscle ultrastructure is familiar with the frequently convoluted appearance of the muscle cell nucleus (e .g . Figs . 1-3) . It is a reasonable assumption that this particular shape of the nucleus can be correlated with the contracted state of the muscle fiber . Lane (12) was able to show that in contracting intestinal smooth muscle cells the nucleus undergoes a change from an ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2012
ISSN: 2041-1723
DOI: 10.1038/ncomms1668